Electronic Library Collections and Users with Visual Impairments: Challenges, Developments, and the State of Collections Policies in Academic and Public Libraries

Academic and public library collections are developed based on the needs of the communities that surround them. Technology has increased the way users access information, and the way libraries offer information to their users. However, the accessibility of electronic resources for users with print disabilities remains an issue that has yet to have an equitable remedy. This paper identifies the challenges of visually impaired users, the developments in law, the current state of accessibility in academic and public library collections policies, and the current formats and products that are leading the way

Micromechanics of deformation in porous liquid phase sintered alumina under hertzian contact

A series of fine-grained porous alumina samples, with and without a liquid phase, were fabricated in compositions matched closely to commercially available alumina used as a microelectronic substrates. Hertzian indentation on monolithic specimens of the glass-containing samples produced a greater quasi-ductile stress-strain response compared to that observed in the pure alumina. Maximum residual indentation depths, determined from surface profilometry, correlated with the stress-strain results. Moreover, microstructural observations from bonded interface specimens revealed significantly more damage in the form of microcracking and under extreme loading, pore collapse, in the glass-containing specimens. The absence of the typical twin faulting mechanism observed for larger-grained alumina suggests that the damage mechanism for quasi-ductility in these fine-grained porous alumina derived from the pores acting as a stress concentrator and the grain boundary glass phase providing a weak path for short crack propagation

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

Chronic use of inhaled anticholinergics by patients with chronic obstructive pulmonary disease (COPD) has raised long-term safety concerns, particularly cardiovascular. Glycopyrronium is a once-daily anticholinergic with greater receptor selectivity than previously available agents.status: publishe

Langerhans cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody

dendritic cells (DC) form a group of non]ymphoid dendritic cells (NLDC) postulated to act primarily as antigen-presenting or accessory cells, in particular as inducers of T-dependent responses (1-5). The cells originate from bone marrow (3, 6, 7), but although it has been suggested that they belong to the mononuclear phagocyte system (8, 9), a direct relationship with monocyte] macrophage populations has not yet been proven. In contrast to typical macrophages, these DC show little phagocytic activity (10-12), whereas high levels of Ia antigens are constitutively expressed (13-16). LC are described as the primary immunocompetent cell in the skin, playing a role in the presentation of antigen to T cells and the induction of contact sensitivity (2, 4, 17). They can migrate from the skin into the afferent lymph (18, 19) as VC, characterized by their long, actively moving processes (19, 20). During their travel via the afferent lymph, VC can carry antigen, which may be presented to lymphocytes in the draining lymph node (21). Based on morphological criteria and localization patterns after cell transfer, it has been hypothesize